Three treatments were compared to test their relative efficacy (effectiveness) in treating Type 2 Diabetes in patients aged 10-17 who were being treated with metformin. The primary outcome was lack of glycemic control (or not); lacking glycemic control means the patient still needed insulin, which is not the preferred outcome for a patient.
Format
A data frame with 699 observations on the following 2 variables.
- treatment
The treatment the patient received.
- outcome
Whether there patient still needs insulin (
failure) or met a basic positive outcome bar (success).
Source
Zeitler P, et al. 2012. A Clinical Trial to Maintain Glycemic Control in Youth with Type 2 Diabetes. N Engl J Med.
Details
Each of the 699 patients in the experiment were randomized to one of the
following treatments: (1) continued treatment with metformin
(coded as met), (2) formin combined with rosiglitazone (coded as
rosi), or or (3) a lifestyle-intervention program (coded as
lifestyle).
Examples
lapply(diabetes2, table)
#> $treatment
#>
#> lifestyle met rosi
#> 234 232 233
#>
#> $outcome
#>
#> failure success
#> 319 380
#>
(cont.table <- table(diabetes2))
#> outcome
#> treatment failure success
#> lifestyle 109 125
#> met 120 112
#> rosi 90 143
(m <- chisq.test(cont.table))
#>
#> Pearson's Chi-squared test
#>
#> data: cont.table
#> X-squared = 8.1645, df = 2, p-value = 0.01687
#>
m$expected
#> outcome
#> treatment failure success
#> lifestyle 106.7897 127.2103
#> met 105.8770 126.1230
#> rosi 106.3333 126.6667