Efficacy of Pfizer-BioNTech COVID-19 vaccine on adolescents

On March 31, 2021, Pfizer and BioNTech announced that "in a Phase 3 trial in adolescents 12 to 15 years of age with or without prior evidence of SARS-CoV-2 infection, the Pfizer-BioNTech COVID-19 vaccine BNT162b2 demonstrated 100% efficacy and robust antibody responses, exceeding those recorded earlier in vaccinated participants aged 16 to 25 years old, and was well tolerated." These results are from a Phase 3 trial in 2,260 adolescents 12 to 15 years of age in the United States. In the trial, 18 cases of COVID-19 were observed in the placebo group (n = 1,129) versus none in the vaccinated group (n = 1,131).

Usage

biontech_adolescents

Format

A data frame with 2260 observations on the following 2 variables.

group

Study group: vaccine (Pfizer-BioNTech COVID-19 vaccine administered) or placebo.

outcome

Study outcome: COVID-19 or no COVID-19.

Source

"Pfizer-Biontech Announce Positive Topline Results Of Pivotal Covid-19 Vaccine Study In Adolescents". March 21, 2021. (Retrieved April 25, 2021.)

Examples

library(dplyr)
library(ggplot2)

biontech_adolescents |>
  count(group, outcome)
#> # A tibble: 3 × 3
#>   group   outcome         n
#>   <fct>   <fct>       <int>
#> 1 vaccine no COVID-19  1131
#> 2 placebo COVID-19       18
#> 3 placebo no COVID-19  1111

ggplot(biontech_adolescents, aes(y = group, fill = outcome)) +
  geom_bar()