Patient level data on the randomized trial Learning Early About Peanut (LEAP) allergies.
Source:R/data-LEAP.R
LEAP.RdThis study examined whether early exposure to peanuts increased tolerance and protection from developing a peanut allergy in children who are allergic to eggs or who have severe eczema. Participants between 4 and 11 months old were randomized to either avoid versus consume peanut based products during the first three years of life. The longer title of the study is Induction of Tolerance Through Early Introduction of Peanut in High-Risk Children and can be found in https://clinicaltrials.gov/ as study NCT00329784.
Format
A data frame with 640 rows and 7 columns
participant.IDCharacter vector, unique identifier for each participant.
stratumFactor, outcome of a skin prick test (SPT) conducted before randomization, with levels
SPT-Negative, participant shows no evidence of peanut allergy, andSPT-Positive, evidence of a peanut allergy. Participants were randomized separately within each stratum. The primary analysis of the study is typically restricted to the SPT-Negative group.treatment.groupFactor, randomized assignment for each participant, with levels
Peanut AvoidanceandPeanut Consumption
.
age.monthsParticipant age in months at randomization.
sexFactor, sex of participant with levels
FemaleandMaleprimary.ethnicityFactor variable with levels
Asian,Black,Other,Mixed, andWhite.overall.V60.outcomeFactor, indicating whether after 5 years, the participant had an allergic reaction in the OFC, with levels for having a reaction to a peanut based oral food challenge, with levels (
FAIL OFC) (allergic reaction), (PASS OFC) (no allergic reaction)
Source
These data are a subset of variables from the file ADSTART0_2015-03-03_14-20-10.txt, available by downloading study files from https://www.immport.org/shared/study/SDY660