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Data from the Prevention of REnal and Vascular END-stage Disease (PREVEND) study, which took place in the Netherlands. The study collected various demographic and cardiovascular risk factors. This dataset is from the third survey, which participants completed in 2003-2006; data are provided for 4,095 individuals who completed cognitive testing with RFFT.

Usage

prevend

Format

A tibble with 4095 rows and 31 variables:

Casenr

case number, numeric

Age

Numeric, age in years, recorded at time of enrollment.

Gender

Numeric vector: 0 = males; 1 = females.

Ethnicity

Numeric vector: 0 = Western European; 1 = African; 2 = Asian; 3 = Other.

Education

Highest level of education. Numeric: 0 primary school; 1 = lower secondary education; 3 = university.

RFFT

Numeric, performance on the Ruff Figural Fluency Test. Scores range from 0 (worst) to 175 (best).

VAT

Numeric, Visual Association Test score. The VAT is a learning task based on image recognition. Scores may range from 0 (worst) to 12 (best)

CVD

History of cardiovascular event. Numeric vector: 0 = No; 1 = Yes.

DM

Diabetes mellitus (Type 2 diabetes) status at enrollment. Numeric vector: 0 = No; 1 = Yes.

Smoking

Smoking status at enrollment. numeric vector: 0 = No; 1 = Yes.

Hypertension

status of hypertension at enrollment. Numeric vector: 0 = No; 1 = Yes.

BMI

Numeric, body mass index, weight divided by height-squared, in kg/m^2

SBP

Numeric, systolic blood pressure, in mmHg

DBP

Numeric, diastolic blood pressure, in mmHg

MAP

Numeric, mean arterial pressure, in mmHg

eGFR

Numeric, estimated glomerular filtration rate, a measure of kidney function. Low values indicate possible kidney damage, in mL/min.

Albuminuria.1

Albuminuria (mg/24hr) in two categories. Numeric vector: 0 = (< 30); 1 = (\(\ge\) 30)

Albuminuria.2

Albuminuria (mg/24hr) in three categories. Numeric: 0 = (0 to < 10), 1 = (10 to < 30); 3 = (\(\ge\) 30).

Chol

Numeric, total cholesterol, in mmol/L.

HDL

Numeric, HDL cholesterol, in mmol/L.

Statin

Statin use at enrollment. Numeric vector: 0 = No; 1 = Yes.

Solubility

Statin solubility.Numeric vector: 0 = lipophilic; 1 = hydrophilic; 2 = no statin use. NA indicates statin solubility is missing.

Days

Numeric, total duration of statin use, in days. -1 indicates participant did not use statins

Years

Numeric, total duration of statin use, in years. -1 indicates participant did not use statins.

DDD

Defined daily dose of the statin. Numeric vector: From the PLOS One paper, "DDD is defined by the WHO as the drug units representing dosages with approximately similar efficacy. One DDD corresponds to the following dosage for each statin respectively: Simvastatin 30 mg, Pravastatin 30 mg, Fluvastatin 60 mg, Atorvastatin 20 mg and Rosuvastatin 10 mg."

FRS

Framingham risk score. Numeric vector. The score, a measure of risk for a cardivascular event within 10 years. Higher values imply increased use. For details see D’Agostino RBS, Vasan RS, Pencina MJ, Wolf PA, Cobain M, et al. (2008) General cardiovascular risk profile for use in primary care: The Framingham Heart Study. Circulation 117: 743–753.

PS

Propensity score of statin use. Numeric vector. See the PLOS One paper for the model used to calculate the score

PSquint

Quintile of PS. Numeric vector.

GRS

Indicator for random sample of 1638 Groningen residents in the study. Numeric vector.

Match_1

Numeric, statin users and non-users matched 1:1 on age and educational level. Matched pairs share a common integer label. -1 indicates participant not matched.

Match_2

Numeric, statin users and non-users matched 1:1 on Framingham risk score. Matched pairs share a common integer label. -1 indicates participant not matched

References

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0115755